• Introduction
• API Development and Manufacture
  • Medicinal Chemistry Support
  • First in Man (Rapidd™)
  • Intermediate and API Supplies
  • Supporting Capabilities
• Solid State Services
  • Polymorph Screening Service
  • Crystal Engineering
  • Crystal Form Selection
  • Characterisation
  • Pharma Expert Witness
• Analytical
  • Method Development and Validation
  • Physical and Chemical Characterisation
  • Product Testing
  • Stability Testing
  • Facilities and Instrumentation
• Peptides and Proteins
  • GMP Peptide API
  • Custom Peptides
  • Immunograde Peptides
  • Chemokines
  • Site Specific PEGylation
    • Ligation Technology
    • Application to PEGylation
  • Facilities and Equipment
  • Quote
• Isotope Chemistry
  • Chemistry
  • Analysis
  • cGMP
  • Labels
• Biocatalysis
  • Biocatalysis Services
  • Biocatalysis Expertise
  • Enzyme Kits
  • Process Development
  • Chiral Building Blocks
  • Enzyme Screening
  • Fermentation & Molecular Biology
  • Purification
  • Enzyme Kit Quotation Request

Labels

Radio Isotopes
¹⁴C labelling is a highly flexible cost effective solution for radiolabelled
products particularly for use in ADME studies. Additional benefits are that
high specific activities can be achieved, with avoidance of the lability
challenges encountered with ³H labelling. Relative safety is assured through
low energy beta decay and the long halflife of ¹⁴C results in insignificant
loss of label due to decay.

Stable Isotopes
²H, ¹³C, and ¹⁵N stable labels are available. We will assess potential lability, stability and metabolism issues and recommend the best isotope and label position.

There are no radiation safety issues and isotopic enrichments greater than 98% are typically available. High sensitivity of detection is assured through state-of-the-art mass spectrometry, while multiple labelling can deliver complete mass resolution from an unlabelled analogue.

And by the way...

Our additional label capabilities include:

• Peptide-dye conjugates
• Alexafluor™
• BODIPY™