Transaminase

Almac is currently developing and evaluating a range of TAm enzymes for both in-house screening and for customer screening.  The evaluation consists of R/S selectivity screening, solvent tolerance, reproducibility and methods to ensure high yield where limited by the equilibrium.

• Transaminases are useful for the synthesis of chiral amines.
• Since the reaction is reversible, the enzyme can be used either for the asymmetric conversion of a ketone to a chiral amine or for a bioresolution.
• These enzymes are stereoselective and exhibit a very broad substrate range.

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