Aldehyde Reductases

Aldehyde reductases (AREDs) are useful for the synthesis of primary alcohols by enzymatic reduction of aldehydes. They can also be used to selectively reduce an aldehyde in the presence of a ketone, or in the presence of other aldehydes. These enzymes exhibit a broad substrate range.

• AREDs reduce aldehydes to primary alcohols.
• AREDs reduce aldehydes in the presence of ketones.
• AREDs can regioselectively reduce an aldehyde in the presence of other aldehydes

The ARED catalysed reduction of the aldehyde moiety requires cofactor (NADH or NADPH) regeneration and is carried out with either isopropyl alcohol or with glucose dehydrogenase as shown below.

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